Vitamin B12 function may be diminished by excessive folate

When folic acid was added to enriched grains, some scientists warned that this was the largest experiment ever done in American history. While folic acid prevents neural tube defects in developing fetuses, the high levels of synthetic folate is apparently , One of the problems is increased homocysteine levels, which is a marker associated with heart disease (a far stronger marker than cholesterol, BTW). This means that people need to make sure to have adequate B-12. High folate and normal to high B-12 is beneficial. For those who do not eat sufficient amounts of animal products, supplements may be advised.